Single enantiomer epoxides by bromomandelation of prochiral alkenes.
نویسندگان
چکیده
A combination of mandelic acid and N-bromosuccinimide efficiently converts prochiral alkenes into a readily separable 1:1 mixture of the bromomandelates. The diastereomerically pure bromomandelates are then converted into a variety of enantiomerically pure products. Terminal alkenes are converted into enantiomerically pure epoxides. Cyclohexene is converted into enantiomerically pure cis-2-azidocyclohexanol and cis-2-phenylthiocyclohexanol.
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ورودعنوان ژورنال:
- The Journal of organic chemistry
دوره 72 2 شماره
صفحات -
تاریخ انتشار 2007